2-Pyrrolidone → 10-(1-Pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine

HRID 1657788Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1657788
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[O:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]=2[CH:4]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][C:20]1=O.P(Cl)(Cl)(Cl)=O>>[N:19]1[CH2:23][CH2:22][CH2:21][C:20]=1[N:6]1[C:5]2[CH:4]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:16]=[CH:15][C:14]=2[O:13][C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2

Komponenten

4

Edukt 3

HCID 120252-PyrrolidoneHCID 24813Phosphorus oxychlorideHCID 104673212-Trifluoromethylphenoxazine

Produkt 1

HCID 2275428010-(1-Pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine

Versuchsvorschrift

Reaction of 2-(trifluoromethyl)phenoxazine, 2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 10-(1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE as a distillable oil, b.p. 140°-146°C. at 0.1 mm Hg. Conversion of the free base to the hydrochloride salt affords 10-(1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE HYDROCHORIDE, m.p. 219.5°-222.5°C. (dec.)(corr.), in a 62% overall yield by triturating with warm benzene.

Quellen und Nachweise

ORD-Eintrag
ord-5af2fc4ad7154ac2b2f69635bdd7c0dc
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03962252

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