Pyrrolidine → HCID 21530393, compound

Participants

Reaction Steps

A solution of 20.6 g (0.1 mol) of 3,4-dihydro-1-benzothiepin-5(2H)-one 1,1-dioxide, 9.6 g of pyrrolidine and 250 mg of p-toluenesulfonic acid in 250 ml of benzene was refluxed under a nitrogen atmosphere for 20 hours, using a Dean-Stark apparatus to remove the water which formed. Removal of the solvent under reduced pressure gave 27 g of a viscous oil which was used without further purification. The infrared spectrum showed the absence of a ketone band and the presence of a strong enamine band at 1620 cm-1.

Provenance & Evidence