Diethyl Ether → HCID 131710314, compound

Participants

Reaction Steps

To a solution of 2.2 g of maleic acid in 40 ml of ethyl acetate was added 3.9 g of 1-methyl-3-(3-fluorophenacyl)-piperidine, followed by the addition of diethyl ether. The oil which separated was induced to crystallize and the resulting crystals were isolated by filtration and recrystallized from ethyl acetate to give 4.4 g of 1-methyl-3-(3-fluorophenacyl)-piperidine, maleate salt. The following elemental analysis was obtained;

Provenance & Evidence