Hydrochloric Acid → HCID 21530375, compound

Participants

Reaction Steps

1-Methyl-3-(2-chlorophenacyl)piperidine, 24.8 g, was dissolved in 100 ml of diethyl ether. To the resulting solution was added an excess of ethereal hydrogen chloride solution. A heavy oil separated. The solvent was distilled under reduced pressure and acetone was added to the residue. The resulting mixture was heated on a steam-bath until the residue had crystallized. The mixture was cooled, filtered, and thoroughly washed with diethyl ether, giving 26.7 g of 1-methyl-3-(2-chlorophenacyl)piperidine hydrochloride, mp 136°-138°. A small portion of the salt was recrystallized from acetone to give an analytical sample, mp 135.5°-138°, from which the following elemental analysis was obtained:

Provenance & Evidence