Piperidine → HCID 131710316, compound

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Reaction Steps

The procedure of Example 6 was repeated, using 82 ml of the same Grignard reagent solution, except that the 4-chlorobenzonitrile was replaced with 6.2 g of anisonitrile. The yield of crude 1-methyl-3-(4-methoxyphenacyl)piperidine was 7.3 g, bp 134°-138°/0.1 mm. Conversion of the piperidine compound to the maleate salt utilized 4.4 g of maleic acid with appropriate increases in solvent volumes. The crude salt thus obtained, 10.7 g, mp 91°-94°, was recrystallized to give 9.5 g of 1-methyl-3-(4-methoxyphenacyl)piperidine, maleate salt, mp 89°-92°. The following elemental analysis was obtained:

Provenance & Evidence