Cyanogen Bromide → HCID 21530358, compound

HRID 1657831Notes

Reaction equation

HRID 1657831 reaction equation
[N:1]#CBr.[CH3:4][N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([CH2:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[O:13])[CH2:6]1>C1C=CC=CC=1>[C:4]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([CH2:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[O:13])[CH2:6]1)#[N:1]

Participants

4

Reactant 2

HCID 10476Cyanogen BromideHCID 21530368HCID 21530368, compound

Product 1

HCID 21530358HCID 21530358, compoundYield 66.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The procedure of Example 19 was repeated, using 9.5 g of cyanogen bromide, 19.3 g of 1-methyl-3-(2-fluorophenacyl)piperidine (Example 5), and an additional 130 ml of benzene. The final residue, 16.3 g, was vacuum distilled to give 13.5 g of 1-cyano-3-(2-fluorophenacyl)piperidine, bp 190°-195°/0.5 mm. The following elemental analysis was obtained:

Workup

  1. distillationdistilled

Sources & evidence

ORD record
ord-f0383171bacf41bbb9117af4e696409a
Source dataset
uspto-grants-1976_06
Patent number
US03962257

Reaction notes

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