2-Amino-2-methyl-1,3-propanediol → HCID 21414467, compound

Participants

Reaction Steps

53 g of cyclobutane-1,2-dinitrile were heated for 3.5 hours to 100°C with 150 g of 2-hydroxymethyl-2-amino-1-propanol in the presence of 0.5 g of CuCl. Distillation of the reaction mixture in the same way as described in Example 15 gave 175 g of distillate boiling at 142° - 200°C/0.6 Torr which, when subsequently fractionated in a Vigreux column, gave 117 g (83% of the theoretical) of 1,2-bis-(4-methyl-4-hydroxymethyl oxazolin-2-yl)-cyclobutane boiling at 198° - 204°C/0.05 Torr.

Provenance & Evidence