HCID 21506829, compound → HCID 21506816, compound

HRID 1657841Notes

Reaction equation

HRID 1657841 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][C:16]=1[O:17][CH3:18])[C:8]1([CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[O:7][C:6]2=[O:19].C1OC(C2C=CC=CC=2)(C(F)CC)OC1.Cl[CH:36]([CH2:46][CH3:47])[C:37]([C:39]1[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=1)=[O:38]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][C:16]=1[O:17][CH3:18])[C:8]1([CH2:13][CH2:12][N:11]([CH2:47][CH2:46][CH2:36][C:37](=[O:38])[C:39]3[CH:40]=[CH:41][C:42]([F:45])=[CH:43][CH:44]=3)[CH2:10][CH2:9]1)[O:7][C:6]2=[O:19]

Participants

3

Reactant 2

HCID 21506829HCID 21506829, compoundHCID 131710318HCID 131710318, compound

Product 1

HCID 21506816HCID 21506816, compound

Procedure

Reaction of 1,3-dihydro-5,6-dimethoxyspiro-[isobenzofuran-1,4'-piperidine]-3-one and αchloro-p-fluorobutyrophenone fluorobutyrophenone ethylene ketal by the method described in Example 6 provides 1,3-dihydro-5,6-dimethoxy-1'-[3-(4-fluorobenzoyl)propyl]spiro[isobenzofuran-1,4'-piperidine] -3-one.

Sources & evidence

ORD record
ord-c0e2070297204ffcb19fe6f3aa4de1e5
Source dataset
uspto-grants-1976_06
Patent number
US03962259

Reaction notes

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