Hexane → Lithium cyclohexylisopropylamide

Participants

Reaction Steps

A flamed-out flask under a nitrogen atmosphere was charged with 175 ml of a hexane solution containing 0.35 mole of n-butyllithium. The flask was immersed in an ice bath and 52 g (0.37 mole) of N-isopropylcyclohexylamine was added dropwise over a 10 minute period. The ice bath was removed and stirring was continued for 10 additional minutes. The hexane was removed under reduced pressure with an oil pump to leave a white residual solid which was dissolved in 1000 ml of tetrahydrofuran.

Provenance & Evidence