Dicyclohexylcarbodiimide → HCID 86732894, compound

HRID 1657908Notes

Reaction equation

HRID 1657908 reaction equation
[CH3:1][NH:2][O:3][CH3:4].[CH3:5][C:6]1[C:11]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:21][C:22]([OH:24])=O.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[CH3:4][O:3][N:2]([CH3:1])[C:22](=[O:24])[CH2:21][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]([C:12](=[O:20])[C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[C:6]=1[CH3:5]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 14232N,O-DimethylhydroxylamineHCID 20455613HCID 20455613, compound

Product 1

HCID 86732894HCID 86732894, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1 ml of N,O-dimethylhydroxylamine was added progressively to a mixture of 2.88 g of 2-methyl-3-(p-chlorobenzoyl)-phenylacetic acid and 2.06 g. of dicyclohexylcarbodiimide in 50 ml of chloroform and the mixture was stirred for 4 hours at room temperature. The precipitate was filtered off and the filtrate was evaporated to dryness to obtain N-methoxy-N,2-dimethyl-3-(p-chlorobenzoyl)-phenylacetamide.

Workup

  1. filtrationThe precipitate was filtered off
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-e45616b49ec943c18c138a777511c412
Source dataset
uspto-grants-1976_06
Patent number
US03962303

Reaction notes

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