反应详情

温度

25 °C

A solution of 58 parts of 2,6-diethylacetanilide in 100 parts of glacial acetic acid and 184 parts of concentrated sulfuric acid is treated at 10° with a mixture of 19.5 parts by volume of concentrated nitric acid and 13 parts by volume of concentrated sulfuric acid. After addition is completed, the mixture is stirred at 25°C for 1 hour. It is then poured into water and ice, and the solid filtered, washed with water and dried. The 2,6-diethyl-4-nitroacetanilide (30 parts) is treated with 150 parts by volume of refluxing 70% sulfuric acid solution for one hour, and the mixture poured onto ice and made basic with 5N sodium hydroxide solution. The solid 2,6-diethyl-4-nitroaniline is filtered, washed with water and recrystallized from methyl alcohol-water.

1. additionAfter addition
2. filtrationthe solid filtered
3. washwashed with water
4. customdried
5. additionThe 2,6-diethyl-4-nitroacetanilide (30 parts) is treated with 150 parts by volume
6. temperatureof refluxing 70% sulfuric acid solution for one hour
7. additionthe mixture poured onto ice
8. filtrationThe solid 2,6-diethyl-4-nitroaniline is filtered
9. washwashed with water
10. customrecrystallized from methyl alcohol-water