反应详情

温度

150 °C

To a flask equipped with stirrer, thermometer, condenser, addition funnel and heating mantle, there is added 44.0 grams (0.25 mole) of p-pivaloyl toluene at a temperature of 150°C. There is then added dropwise, while maintaining the temperature at 150°C., 40 grams (0.25 mole) of liquid bromine over a period of 10 to 15 minutes. The mixture is then stirred for an additional 10 minutes again while maintaining the temperature at about 140° to 150°C. The resulting brown liquid is cooled and degassed with nitrogen to obtain α-bromo-4-pivaloyl toluene in liquid form, b.p. 124° to 132°C. at 0.3 mm.

1. customTo a flask equipped with stirrer
2. additionthermometer, condenser, addition funnel
3. temperatureheating mantle, there
4. additionThere is then added dropwise
5. temperaturewhile maintaining the temperature at about 140° to 150°C
6. temperatureThe resulting brown liquid is cooled
7. customdegassed with nitrogen