反应详情

温度

50 °C

A solution of 34.3 g. (0.700 mole) sodium cyanide in 40 ml. of water is warmed to 50°C. and a solution of α-bromo-4-pivaloyl toluene in 85 ml. ethanol is then added dropwise at such a rate as to maintain the temperature at 50°C. After the addition is complete, the mixture is refluxed for four hours. The excess ethanol is removed in vacuo and the resulting residue is treated with ether/water. The layers are separated and the ether is washed with cold 50% sulfuric acid, water and sodium bicarbonate; then the ether layer is dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo. The residue is distilled in vacuo to give 4-pivaloylphenyl acetonitrile (b.p. 143°-148°C/0.75 mm n22 =1.5244.)

1. additionAfter the addition
2. temperaturethe mixture is refluxed for four hours
3. customThe excess ethanol is removed in vacuo
4. additionthe resulting residue is treated with ether/water
5. customThe layers are separated
6. washthe ether is washed with cold 50% sulfuric acid, water and sodium bicarbonate
7. dry with materialthen the ether layer is dried over anhydrous magnesium sulfate
8. filtrationfiltered
9. customevaporated in vacuo
10. distillationThe residue is distilled in vacuo