p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Steps

A solution of trichloroethyl N-benzylidene-α-amino-diethylphosphonoacetate (5.69 g., 13.2 mmole) in ethyl ether (25 ml.) is added to a rapidly stirring solution of p-toluenesulfonic acid monohydrate (2.76 g., 14.5 mmole) in ethyl ether (75 ml.). A white precipitate appears immediately. The mixture is stirred for 10 minutes at room temperature, then cooled in ice. The product is collected by suction filtration, washed with cold ethyl ether, and dried in vacuo to give trichloroethyl α-aminodiethylphosphonoacetate, p-toluenesulfonate (6.03 g.) as a white powder.

Provenance & Evidence