反应详情

温度

80 °C

A solution of 2-azido-2-methoxyacetic acid (4.2 g.) in thionyl chloride (10 ml.) is heated in an oil bath maintained at 80°C. for 20 minutes. After cooling to room temperature, the mixture is evaporated in vacuo to remove excess thionyl chloride and the residue is distilled to yield 2-azido-2-methoxyacetyl chloride (2.26 g.) as a water-white liquid (b.p. 64°-66°C./27 mm.).

1. temperatureAfter cooling to room temperature
2. customthe mixture is evaporated in vacuo
3. customto remove excess thionyl chloride
4. distillationthe residue is distilled