Potassium Carbonate → HCID 20357827, compound

Participants

Reaction Steps

A solution of p-bromophenacyl α-thioformamido-dibutylphosphonoacetate (6.10 g) in acetone (50 ml) is treated with powdered potassium carbonate (4.98 g). The mixture is stirred under a nitrogen atmosphere while 1-chloro-3-isobutyryloxy-2-propanone (2.32 g) in acetone (10 ml) is added dropwise over 10 minutes. The reaction mixture is stirred an additional 3 hours at room temperature, then filtered. Evaporaton of the filtrate under reduced pressure leaves a dark oil which is extracted with carbon tetrachloride (2 × 50 ml). The combined extracts are washed with 0.5 M dipotassium hydrogen phosphate, water, and saturated brine, dried over magnesium sulfate, and evaporaged in vacuo to give crude p-bromophenacyl 5-isobutyryloxymethyl-6H-1,3-thiazine-4-carboxylate.

Provenance & Evidence