Hydrochloric Acid → 10-Trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3-(2H)-dione

Participants

Reaction Steps

A stirred suspension of 53.6 g. (0.146 mol.) of 1-methylmercapto-10-trifluoromethyl-3H-pyrimido[5,4,3-kl]phenothiazine-3-one in 240 ml. of concentrated hydrochloric acid and 800 ml. of ethanol was heated under reflux for four hours. The reaction mixture was concentrated to approximately one-half its original volume by boiling off the excess solvents and chilled. The product was collected by filtration and washed thoroughly with water to give the title compound, m.p. 278°-280° (ethanol).

Provenance & Evidence