HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Hydroxy-3-nitrophenyl)propanenitrile → 2-(3-Amino-4-hydroxyphenyl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Hydroxy-3-nitrophenyl)propanenitrile | HCID 12202635 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(3-Amino-4-hydroxyphenyl)propanenitrile | HCID 12202636 | 52.4% |
Reaction Steps
2-(3-Nitro-4-hydroxyphenyl) propionitrile (38.4 g., 0.2 mole.) was suspended in absolute ethanol (250 ml.) and hydrogenated at 4 atmospheres pressure and room temperature over 10% palladium on charcoal. Hydrogenation was complete in 3.8 hours. The catalyst was removed by filtration. Evaporation of the filtrate yielded 2-(3-amino-4-hydroxyphenyl) propionitrile (17 g.), m.p. 110°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03962441 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-b0aedd3d8e104c6ca6c61f54abe6e90c |
| Source note | uspto-grants-1976_06 |