HCID 53929795, compound → 2-[2-(2-Chlorophenyl)-1,3-benzoxazol-6-yl]propanoic acid

HRID 1658084Notes

Reaction equation

HRID 1658084 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[CH:16]=[C:15]([CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])[CH:14]=[CH:13][C:11]=2[N:12]=1>[OH-].[Na+]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[CH:16]=[C:15]([CH:17]([CH3:23])[C:18]([OH:20])=[O:19])[CH:14]=[CH:13][C:11]=2[N:12]=1

Participants

3

Reactant 1

HCID 53929795HCID 53929795, compound

Product 1

HCID 399622-[2-(2-Chlorophenyl)-1,3-benzoxazol-6-yl]propanoic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The ethyl 2-(2-o-chlorophenyl-6-benzoxazolyl)propionate from (a) was stirred with sodium hydroxide solution (50 ml.). After 11/2 hours the solution was evaporated to dryness. Acidification and re-crystallisation from ether gave 2-(2-o-chlorophenyl-6-benzoxazolyl)-propionic acid, m.p. 108°- 110°C.

Workup

  1. customAfter 11/2 hours the solution was evaporated to dryness
  2. customAcidification and re-crystallisation from ether

Sources & evidence

ORD record
ord-c46e80eb1e2244d1aa97a54855e0bb4b
Source dataset
uspto-grants-1976_06
Patent number
US03962441

Reaction notes

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