Nitric Acid → 1-Ethyl-4-hydroxy-3-nitro-1H-quinolin-2-one

Participants

Reaction Conditions

Reaction Steps

A suspension of 1-ethyl-4-hydroxy carbostyril (1.09 g; 0.00575 mole) in glacial acetic acid (5 ml) was swirled during the rapid addition of concentrated nitric acid (1.25 ml; d 1.42) and the dark liquid heated for 5 minutes at 100°C. The yellow solid which separated on cooling was filtered off and washed well with ethanol m.p. 154°-5°C (decomp). (Found;C, 56.54; H, 4.52; N, 11.56; C11H10N2O4 requires; C, 56.41; H, 4.30, N, 11.96%).

Provenance & Evidence