Acetic Acid → HCID 12883909, compound

HRID 1658119Notes

Reaction equation

HRID 1658119 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][NH:16][C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].S(OCC)(O[CH2:28][CH3:29])(=O)=O.C(O)(=O)C>C(=O)([O-])[O-].[Na+].[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][N:16]([CH2:28][CH3:29])[C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6163Diethyl SulfateHCID 128507552-(4-Acetyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid

Product 1

HCID 12883909HCID 12883909, compound

Reagents, catalysts & solvents 1

HCID 10340Sodium CarbonateSolvent

Procedure

To a solution of 0.45 g of 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid in 30 ml of sodium carbonate was added two 0.5 ml portions of diethyl sulfate with stirring at room temperature. After the completion of the reaction the mixture was neutralized with acetic acid. The precipitate resulted was collected and recrystallized from dimthylformamide to yield 0.4 g of the product, m.p. 298° - 300°C.

Workup

  1. customAfter the completion of the reaction the mixture
  2. customThe precipitate resulted
  3. customwas collected
  4. customrecrystallized from dimthylformamide

Sources & evidence

ORD record
ord-bc368523f23642bbb9c0d7feac13cecf
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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