2-Chloroethanol → HCID 15574554, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 5.0 g of ethyl 5,8-dihydro-2-(4-methyl-1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate, 70 ml of dimethylformamide, 0.90 g of 50% sodium hydride, and 3.8 g of ethylene chlorohydrin was heated at 100°C for one hour. Dimethylformamide was distilled off in vacuo, and the residue taken up in chloroform. The chloroform solution was washed with water, dried over anhydrous magnesium sulfate, and the solvent distilled off. The resulting solid was recrystallized from ethanol to yield 4.6 g of the product, m.p. 197° - 199°C.

Provenance & Evidence