1,2-Dimethoxyethane → HCID 12266831, compound

HRID 1658125Notes

Reaction equation

HRID 1658125 reaction equation
C([O:3][C:4]1[C:13]2[CH:12]=[N:11][C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)=[N:9][C:8]=2[N:7]=[CH:6][C:5]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22])C.CO[CH2:28][CH2:29]OC>>[CH2:28]([N:7]1[C:8]2[N:9]=[C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[N:11]=[CH:12][C:13]=2[C:4](=[O:3])[C:5]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:6]1)[CH3:29]

Participants

3

Reactant 2

HCID 80711,2-DimethoxyethaneHCID 21532573HCID 21532573, compound

Product 1

HCID 12266831HCID 12266831, compound

Procedure

A mixture containing 1.0 g of ethyl 5-ethoxy-2-(4-methyl-1-piperazinyl)pyrido[ 2,3-d]pyrimidine-6-carboxylate and 5.0 ml of dimethylene glycol dimethyl ether was heated to reflux for 3 hours. The solvent was removed by distillation is vacuo and the residual solid was recrystallized from water to yield 0.72 g of the product, m.p. 146° - 147°C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 hours
  3. customThe solvent was removed by distillation
  4. customthe residual solid was recrystallized from water

Sources & evidence

ORD record
ord-40f3668e52cb400c87eee685e91bdc94
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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