HCID 21532578, compound → 8-Benzyl-5,8-dihydro-2-(1-piperazinyl)-5-oxopyrido [2,3-d]pyrimidine-6-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Ethyl 8-benzyl-5,8-dihydro-2-(1-piperazinyl)5-oxopyrido[2,3-d]pyrimidine-6-carboxylate (1.5 g) was dissolved in 20 ml of a 12% aqueous solution of sulfuric acid by heating at 90°C for one hour. The resulting solution was filtered to remove a small amount of the insoluble material and the filtrate was neutralized with 28% aqueous ammonia, to separate a solid which was collected, washed with water, and recrystallized from dimethylformamide. There is obtained 1.1 g of the product, m.p. 250° -253°C.

Provenance & Evidence