反应详情

温度

90 °C

Ethyl 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate (5.0 g) was dissolved in 35 ml of a 10% aqueous solution of sodium carbonate by heating at 90°C for 30 minutes. The resulting solution was filtered to remove the insoluble material, and the filtrate was neutralized with acetic acid to give a precipitate which was collected and recrystallized from a mixture of benzene and chloroform. There is obtained 4.1 g of the product, m.p. 298° - 300°C.

1. filtrationThe resulting solution was filtered
2. customto remove the insoluble material
3. customto give a precipitate which
4. customwas collected
5. customrecrystallized from a mixture of benzene and chloroform