HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1658143Generated: November 2, 2026
Benzoyl chloride → Benzamide, N-[5-(1-cyanoethyl)-2-hydroxyphenyl]-
https://huagongshe.com/reaction/1658143
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 2-(3-Amino-4-hydroxyphenyl)propanenitrile | HCID 12202636 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Benzamide, N-[5-(1-cyanoethyl)-2-hydroxyphenyl]- | HCID 12202639 | — |
Reaction Steps
Benzoyl chloride (27.09 g., 0.19 mole.) was added, with cooling, during 20 minutes to a stirred solution of 2-(3-amino-4-hydroxyphenyl) propionitrile (28.35 g., 0.175 mole.) in dry pyridine (200 ml.) at 0°-3°C. After addition was complete, the mixture was heated at 100°C. for 1 hour. It was then evaporated under reduced pressure to yield crude 2-(3-benzamido-4-hydroxyphenyl) propionitrile as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03962452 |
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| Source dataset | uspto-grants-1976_06 |
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| ORD ID | ord-b2d03be4fbda47eaab618287d8693c68 |
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| Source note | uspto-grants-1976_06 |
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