HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Amino-4-hydroxyphenyl)acetic acid → 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Amino-4-hydroxyphenyl)acetic acid | HCID 1473103 | — |
| Reactant | Ether hydrochloride | HCID 10953452 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)- | HCID 3039778 | — |
Reaction Steps
A suspension of p-chlorobenzimidoethyl ether hydrochloride (16.5 g.) and 3-amino-4-hydroxyphenylacetic acid (12.53 g.) in methanol (75 ml.) was refluxed for 2 hours. After standing at room temperature overnight the white solid product was removed by filtration. Re-crystallisation from ethanol gave the required acid, m.p. 241°-242°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03962452 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-48d6624345e648808b536f9b4beaf16d |
| Source note | uspto-grants-1976_06 |