Ethanol → HCID 178478543, compound

HRID 1658188Notes

Reaction equation

HRID 1658188 reaction equation
Cl.[Cl:2][C:3]1[CH:16]=[CH:15][C:6]([CH:7]([NH2:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[CH2:17](O)[CH3:18]>COC1CCCCCN=1>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([CH:7]([N:14]=[C:18]2[CH2:17][CH2:4][CH2:5][CH2:6][CH2:7][NH:14]2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 162190964-Chlorobenzhydrylamine hydrochloride

Product 1

HCID 178478543HCID 178478543, compound

Reagents, catalysts & solvents 1

HCID 756572H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-Solvent

Procedure

A slurry of 12.0 g of 4-chlorobenzhydrylamine hydrochloride in 23 ml of O-methylcaprolactim was allowed to stand at room temperature for 3 days and was stirred occasionally with a glass rod. At first, the mixture became nearly homogeneous and then it began to solidify. Small amounts of anhydrous ethanol were added to keep the mixture in a stirrable slurry. The mixture was then cooled, the solid was collected and washed with ether and was recrystallyzed twice from methanol-acetone to give 11.7 g of the title compound, m.p. 238°-240°C. The identity of the compound was confirmed by micro-analysis, infrared and ultraviolet spectra.

Workup

  1. temperatureThe mixture was then cooled
  2. customthe solid was collected
  3. washwashed with ether

Sources & evidence

ORD record
ord-d31722294f154a6792abf3ef89cbd99b
Source dataset
uspto-grants-1976_06
Patent number
US03963701

Reaction notes

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