2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → HCID 178478953, compound

HRID 1658189Notes

Reaction equation

HRID 1658189 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH:6]([NH2:13])C2C=CC=CC=2)=CC=1.COC1CCCCCN=1.[F:25][C:26]1[CH:39]=[CH:38][C:29]([CH:30]([NH2:37])[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:28][CH:27]=1.COC1CCCCN=1>>[ClH:1].[F:25][C:26]1[CH:27]=[CH:28][C:29]([CH:30]([N:37]=[C:6]2[CH2:5][CH2:14][CH2:15][CH2:2][NH:13]2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:38][CH:39]=1

Participants

5

Reactant 4

HCID 756572H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-HCID 138567o-MethylvalerolactimHCID 409810(4-Chlorophenyl)(phenyl)methanamineHCID 111832724-Fluoro-α-phenylbenzenemethanamine

Product 1

HCID 178478953HCID 178478953, compound

Procedure

By the procedure of Example 1, only substituting respectively for 4-chlorobenzhydrylamine and O-methylcaprolactim, appropriate amounts of 4-fluorobenzhydrylamine and O-methylvalerolactim the title compound was obtained, m.p. 211°-213°C.

Sources & evidence

ORD record
ord-1ba3a5c9f49f49019afc5a3df4ca66bb
Source dataset
uspto-grants-1976_06
Patent number
US03963701

Reaction notes

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