HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 2-Chloro-N-(2-fluoro-4-sulphamoylphenyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 4-Amino-3-fluorobenzene-1-sulfonamide | HCID 4687472 | — |
| Product | 2-Chloro-N-(2-fluoro-4-sulphamoylphenyl)-acetamide | HCID 21528836 | — |
Reaction Steps
2-Fluoro-4-sulphamoyl-aniline (7.6g) and α-chloroacetyl chloride (12.0g) were refluxed together for 60 min. The reaction product was ground in a mortar with ice/water and filtered (8.3g). Recrystallisation from ethyl acetate to give beige needles m.p. 185°-187°
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03963706 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-13936bc16b6d406b8de0c89eab22991d |
| Source note | uspto-grants-1976_06 |