Formaldehyde → 5-Imidizolidinone, 1-(o-chloro-p-sulfamoylphenyl)-3-phenyl-

HRID 1658202Notes

Reaction equation

HRID 1658202 reaction equation
[C:1]1([NH:7][CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[CH:14][C:13]=2[Cl:22])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23]=O>C(O)C.O>[C:1]1([N:7]2[CH2:8][C:9](=[O:10])[N:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[CH:14][C:13]=3[Cl:22])[CH2:23]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 21528839HCID 21528839, compound

Product 1

HCID 407115-Imidizolidinone, 1-(o-chloro-p-sulfamoylphenyl)-3-phenyl-

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2-Phenylamino-N-(2-chloro-4-sulphamoylphenyl)-acetamide (34.0g) was dissolved in ethanol (300 ml) and paraformaldehyde (6.0g) in water (600 ml) added. The mixture was refluxed 4 hours, cooled and worked up as in Example 2(c) to yield 20 g m.p. 206°

Workup

  1. temperatureThe mixture was refluxed 4 hours
  2. temperaturecooled
  3. customto yield 20 g m.p. 206°

Sources & evidence

ORD record
ord-c4004da1393c4548bcfe63241977d6ec
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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