Chloroacetyl chloride → HCID 21528833, compound

HRID 1658211Notes

Reaction equation

HRID 1658211 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[S:10](=[O:13])(=[O:12])[NH2:11])[NH2:6].[Cl:16][CH2:17][C:18](Cl)=[O:19]>>[Cl:16][CH2:17][C:18]([NH:6][C:5]1[CH:7]=[CH:8][C:9]([S:10](=[O:12])(=[O:13])[NH2:11])=[C:3]([C:2]([F:1])([F:14])[F:15])[CH:4]=1)=[O:19]

Participants

3

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 10610060HCID 10610060, compound

Product 1

HCID 21528833HCID 21528833, compound

Procedure

3-Trifluoromethyl-4-sulphamoylaniline (24.0g) and α-chloroacetyl chloride (20 ml) were refluxed together 30 mins and the mixture worked up as in Example 2(a) to yield 28 g, m.p. 185°-190°

Workup

  1. customto yield 28 g, m.p. 185°-190°

Sources & evidence

ORD record
ord-2ced4e2cda224b0daba3fb32ebbf0fe2
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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