Formaldehyde → GS 316

HRID 1658214Notes

Reaction equation

HRID 1658214 reaction equation
[CH:1]1([NH:7][CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[CH:14][C:13]=2[Cl:22])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:23]=O>C(O)C.O>[CH:1]1([N:7]2[CH2:8][C:9](=[O:10])[N:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[CH:14][C:13]=3[Cl:22])[CH2:23]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 21528859HCID 21528859, compound

Product 1

HCID 3041012GS 316

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2-Cyclohexylamino-N-(2-chloro-4-sulphamoylphenyl)-acetamide (17.2g) was dissolved in ethanol (150 ml) and paraformaldehyde (3g) in water (300 ml) added. The mixture was refluxed 2 hrs, cooled and filtered. The residue was crystallised from ethanol/petroleum ether. Yield 13.5 g, m.p. 188°-190° .

Workup

  1. temperatureThe mixture was refluxed 2 hrs
  2. temperaturecooled
  3. filtrationfiltered
  4. customThe residue was crystallised from ethanol/petroleum ether

Sources & evidence

ORD record
ord-6f4af0d7433743ea9536943f39a690db
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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