HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1658257Generated: October 26, 2026
Benzene → p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol
https://huagongshe.com/reaction/1658257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 2-Amino-1-(4-fluorophenyl)ethan-1-ol | HCID 9827 | — |
| Reactant | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol | HCID 54097200 | — |
Reaction Steps
To a solution of 6.5 parts of α-(aminomethyl)-p-fluorobenzyl alcohol in 8 parts of xylene are added 5.2 parts of 2-(nitramino)-2-imidazoline. The mixture is heated in an oil-bath to about 160°C. till gas-evolution is ceased (about 15 minutes). The reaction mixture is cooled and treated with benzene and acetone. The product is sucked off and crystallized from 4-methyl-2-pentanone, yielding p-fluoro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 153.4°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03963718 |
|---|
| Source dataset | uspto-grants-1976_06 |
|---|
| ORD ID | ord-b252b6ffac8e4e14b0592270d381b4e7 |
|---|
| Source note | uspto-grants-1976_06 |
|---|
