反应详情

A mixture of 8 parts of α-{2-[N-(2-imidazolin-2-yl)amino]ethyl} benzylalcohol from the preceding step and 36 parts of sulfuric acid 80% is stirred for 3 hours at room temperature. The reaction mixture is poured onto crushed ice and the resulting solution is allowed to stand overnight at room temperature. It is then alkalized with sodium hydroxide solution and the product is extracted with toluene. The extract is dried, filtered and evaporated. The residue is triturated in acetone. The solid product is filtered off and crystallized from acetone, yielding 2,3,5,6,7,8-hexahydro-5-phenylimidazo[1,2-a]pyrimidine; m.p. 145.5°C.

1. additionThe reaction mixture is poured
2. customonto crushed ice
3. waitto stand overnight at room temperature
4. extractionthe product is extracted with toluene
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated
8. customThe residue is triturated in acetone
9. filtrationThe solid product is filtered off
10. customcrystallized from acetone