反应详情

To a solution of 14.2 g. of N-isopropyl-2,3-dihydro-5-benzofuranamine in 300 ml. of glacial acetic acid, cooled to 15°±5°C. is added 4.9 g. of sodium isocyanate. The mixture is stirred at room temperature for 18 hours and then concentrated in vacuo. The residue is treated with 200 ml. of 2N sodium hydroxide solution and then extracted twice with chloroform. The combined chloroform extracts are dried with anhydrous magnesium fulfate, filtered and concentrated in vacuo to obtain an oil of 1-isopropyl-1-(2,3-dihydro-5-benzofuranyl)urea.

1. additionis added 4.9 g
2. concentrationconcentrated in vacuo
3. additionThe residue is treated with 200 ml
4. extractionof 2N sodium hydroxide solution and then extracted twice with chloroform
5. dry with materialThe combined chloroform extracts are dried with anhydrous magnesium fulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo