NaNCO → N-(2,3-Dihydro-1-benzofuran-6-yl)-N-propan-2-ylurea

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Reaction Steps

To a solution of 12.2 g. of N-isopropyl-2,3-dihydro-6-benzofuranamine in 250 ml. of glacial acetic acid, cooled to 15°±5°C. is added 24.0 g. of sodium isocyanate. The mixture is stirred at room temperature for 18 hours and then concentrated in vacuo. The residue is treated with 200 ml. of 2N sodium hydroxide solution and then extracted twice with chloroform. The combined chloroform extracts are dried with anhydrous magnesium sulfate, filtered and concentrated in vacuo to obtain an oil of 1-isopropyl-1-(2,3-dihydro-6-benzofuranyl)urea.

Provenance & Evidence