Formaldehyde → HCID 21528959, compound

HRID 1658291Notes

Reaction equation

HRID 1658291 reaction equation
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]3[CH2:16][CH2:15][O:14][C:12]3=2)[CH:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:6][C:5]1=[O:23])([CH3:3])[CH3:2].O1CCOCC1.[Mn]([O-])(=O)(=O)=O.[K+].C=O>O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]3[CH2:16][CH2:15][O:14][C:12]3=2)[C:7]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[N:6][C:5]1=[O:23])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 312751,4-DioxaneHCID 516875Potassium PermanganateHCID 21529043HCID 21529043, compound

Product 1

HCID 21528959HCID 21528959, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 4.2 g. of 1-isopropyl-3,4,7,8-tetrahydro-4-phenyl-furo[3,2-h]quinazolin-2(1H)-one in 180 ml. of dioxane cooled to 8°±5°C. is added dropwise a solution of 2.3 g. of potassium permanganate in 100 ml. of water. After the addition is completed 1.5 ml. of formalin solution is added. The solids which precipitate are removed by filtration and the filtrate concentrated in vacuo to obtain an oil of 1-isopropyl-7,8-dihydro-4-phenyl-furo[3,2-h]quinazolin-2(1H)-one.

Workup

  1. additionis added dropwise a solution of 2.3 g
  2. additionAfter the addition
  3. customThe solids which precipitate are removed by filtration
  4. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-14e64739f99b4c72877ec169ab4507ce
Source dataset
uspto-grants-1976_06
Patent number
US03963717

Reaction notes

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