Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1658311Notes

Reaction equation

HRID 1658311 reaction equation
[CH3:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])N=1.CC(C)=[O:14]>>[CH3:10][C:4]1([CH3:11])[NH:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2](=[O:14])[CH2:1]1

Participants

3

Reactant 2

HCID 180AcetoneHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidone

Conditions

Temperature
60 °C

Procedure

5.0 g. of Acetonine was dissolved in a mixed solvent comprising 19 g. of acetone and 9.5 g. of another solvent listed below. The solution was added with a catalyst listed below and the mixture was heated at 60°C. for 10 hours in a sealed equipment to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 1 to obtain triacetonamine in a yield as shown hereinbelow.

Workup

  1. additionThe solution was added with a catalyst
  2. customthe reaction
  3. customAfter completion of the reaction
  4. customthe reaction mixture was purified in the same manner as in Example 1

Sources & evidence

ORD record
ord-2d53990b14cc4e8ab716c38a2661207e
Source dataset
uspto-grants-1976_06
Patent number
US03963730

Reaction notes

Loading…