反应详情

To a solution of 3 g. of methyl 3-(p-methoxybenzylthio)picolinate in 50 ml. of ethanol is added 10 ml. of 20% aqueous sodium hydroxide solution and the mixture is warmed on a steam bath for two hours. The alcohol is evaporated off and the residue is cooled and acidified with dilute hydrochloric acid. The precipitate is filtered off, washed with water, dried and recrystallized from methanol to give 3-(p-methoxybenzylthio)picolinic acid, m.p. 170°-172°C.

1. customThe alcohol is evaporated off
2. temperaturethe residue is cooled
3. filtrationThe precipitate is filtered off
4. washwashed with water
5. customdried
6. customrecrystallized from methanol