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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1658361Generated: October 25, 2026

Heptafluorobutyryl Chloride → 5-(Trifluoromethyl)-3-nitro-2-(2,2,3,3,4,4,4-heptafluorobutyramido)pyridine

https://huagongshe.com/reaction/1658361

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHeptafluorobutyryl ChlorideHCID 67810—
Reactant3-Nitro-5-(trifluoromethyl)pyridin-2-amineHCID 10608391—
Product5-(Trifluoromethyl)-3-nitro-2-(2,2,3,3,4,4,4-heptafluorobutyramido)pyridineHCID 20355488—

Reaction Steps

5-(Trifluoromethyl)-3-nitro-2-aminopyridine is reacted with perfluorobutyryl chloride to yield 5-(trifluoromethyl)-3-nitro-2-(2,2,3,3,4,4,4,-heptafluorobutyramido)pyridine, which when hydrogenated yields 6-(trifluoromethyl)-1-hydroxy-2-(perfluoro-n-propyl)-1H-imidazo(4,5-b)pyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03963734
Source datasetuspto-grants-1976_06
ORD IDord-1d6888d8da3a44aea7788a02d1d6b6a0
Source noteuspto-grants-1976_06