Sodium Hydroxide → 2-Amino-5-(4-fluorophenyl)thiophene-3-carboxylic acid

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Reaction Steps

A mixture of ethyl 2-amino-5-(4-fluorophenyl)- 3-thiophene carboxylate (2g), sodium hydroxide (1g) and ethanol (20 ml) was refluxed for 5 hours, cooled and then concentrated. The solid residue was dissolved in water, filtered and acidified at 0°C. The light brown precipitate was collected by filtration to give pure 2-amino-5-(4-fluorophenyl)- 3-thiophene carboxylic acid, m.p. 172°-4°.

Provenance & Evidence