反应详情

温度

60 °C

A mixture of 3,5-diphenyl- 4-pyrazolol (10 g, 0.042 mole), sodium methoxide (2.27 g, 0.042 mole) and methanol (60 ml) is heated at 60°C for 2 hours. Then 1-bromopropane (5.17 g, 0.042 mole) is added slowly (5 minutes) at 60°C. The reaction mixture is then held at 60°C until the reaction is complete by tlc. The mixture is poured into water and the solid formed is isolated by filtration. Recrystallization of the solid from acetonitrile affords white crystals, 7.4 g (63%), melting point 142°-142.5°C.

1. customis then held at 60°C until the reaction
2. customthe solid formed
3. customis isolated by filtration
4. customRecrystallization of the solid from acetonitrile
5. customaffords white crystals, 7.4 g (63%), melting point 142°-142.5°C.