HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Phenyl-2-pyridone → Z-Val-Val-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Phenyl-2-pyridone | HCID 87889 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 6-Hydroxynicotinonitrile | HCID 7062197 | — |
| Reactant | HCID 178493244 | HCID 178493244 | — |
| Reactant | 6-(2-Phenylethyl)pyridin-2(1h)-one | HCID 178516001 | — |
| Reactant | HCID 178516071 | HCID 178516071 | — |
| Reactant | HCID 178517620 | HCID 178517620 | — |
| Product | Z-Val-Val-OMe | HCID 12286262 | — |
Reaction Steps
When the sodium salt of 6-n-amyl-2-hydroxypyridine, 5-cyano-2-hydroxypyridine, 2-hydroxy-4-methoxypyridine, 2-hydroxy-6-phenylpyridine, 2-hydroxy-6-phenethylpyridine or 1-hydroxyisoquinoline is used in place of the sodium salt of 2-hydroxypyridine, the yields of benzyloxycarbonyl-L-valyl-L-valine methyl ester are 72, 83, 81, 76, 80 and 73%, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03963728 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-456cedf57e48427a8f06a5fb10878dd8 |
| Source note | uspto-grants-1976_06 |