Ammonia → HCID 21529368, compound

Participants

Reaction Steps

14 g of 1-(4-acetoxy-2,3-dihydroxybutyl)-7-chloro-5-(2-fluorophenyl)-1, 3-dihydro-2H-1,4-benzodiazepin-2-one are dissolved in 30 ml of methanol, treated with 15 ml of 25% aqueous ammonia and stirred at room temperature for 16 hours. The mixture is then evaporated to dryness and chromatographed on silica gel with ethyl acetate/methanol (9:1 ). The pure fractions are combined and evaporated. There is obtained 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,3,4-trihydroxybutyl)-2H-1,4-benzodiazepin-2-one in the form of a foam.

Provenance & Evidence