Ammonia → HCID 21527602, compound

Participants

Reaction Steps

1.35 g of 4-(3-allylamino-2-hydroxypropoxy)oxindole are converted into the hydrochloride, are then dissolved in 15 cc of hexamethyl-phosphoric acid triamide and allowed to stand at room temperature for 70 hours with 1.45 g of adamantane-1-carboxylic acid chloride. The mixture is poured into water, is rendered alkaline with a 10% ammonia solution and is extracted with methylene chloride. The evaporation residue of the methylene chloride phase is chromatographed on silica gel with methylene chloride and 1% of methanol, and the resulting title compound is converted into its hydrogen oxalate. M.P. 170°-172° from ethanol.

Provenance & Evidence