2-Amino-3-Hydroxypyridine → HCID 12354095, compound

Participants

Reaction Steps

A solution of 22.0 g of 2-amino-3-pyridinol, 62.4 g of ethyl cyclopentanone-2-carboxylate, and 200 ml of diethylbenzene is stirred and heated by means of oil bath maintained at ca. 150° for 1 hour, then gradually raised to 195°, and kept at 195° for 1 hour. Some tarry products are formed; hence the diethylbenzene solution is decanted from the tar and the diethylbenzene solution concentrated in vacuo. The residue, 29.8 g is recrystallized from 1400 ml of Skellysolve E to give 22.4 g of product, mp 136°-142°.

Provenance & Evidence