Benzyl Bromide → HCID 12354099, compound

Participants

Reaction Steps

A suspension of 2,3-dihydro-5-hydroxycyclopenta[d]pyrido[1,2-a]pyrimidin-10(1H)-one prepared as described in Example 1, (6.1 g), 9.9 g of anhydrous potassium bicarbonate, 6.2 g of benzyl bromide, and 300 ml of ethyl methyl ketone is stirred and slowly heated to reflux. Stirring and heating under reflux is continued for 18 hours. The hot solution is filtered to remove inorganic salts and the ethyl methyl ketone filtrate is concentrated in vacuo to give 10.0 g of crude product; this, when recrystallized from 1000 ml of cyclohexane, and the crystalline solid dried at 78° for 2 hours, gives 6.0 g of product, mp 150°-152°.

Provenance & Evidence