2-Amino-3-methylpyridine → HCID 12354097, compound

Participants

Reaction Steps

A mixture of 10.8 g of 2-amino-3-picoline, 31.2 g of ethyl cyclopentanone-2-carboxylate, and 250 ml of ethylene glycol monomethyl ether is stirred and heated under reflux for 40 hours. The solution is concentrated as far as possible on a rotary evaporator. The residual oil crystallizes and is filtered with suction to give 14.15 g of air-dried solid. This is recrystallized from 425 ml of cyclohexane to give 11.3 g of product, after drying at 78°. The melting point is 100°-102°.

Provenance & Evidence