Ammonia → HCID 21527672, compound

HRID 1658504Notes

Reaction equation

HRID 1658504 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:11]([C:12](OC)=[O:13])[C:6]2=[N:5][C:4]2[CH2:16][CH2:17][CH2:18][C:3]1=2.[NH3:19]>CO>[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:11]([C:12]([NH2:19])=[O:13])[C:6]2=[N:5][C:4]2[CH2:16][CH2:17][CH2:18][C:3]1=2

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 86733571HCID 86733571, compound

Product 1

HCID 21527672HCID 21527672, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2.44 g. of the product from Example 5 in 50 ml of methanol is cooled to -10° and a stream of dry ammonia gas is introduced. When the increase in weight of the absorbed ammonia is 3.4 g., the addition is stopped, the flask is sealed, and kept at 20°-25° for 24 hours. The solid that separates is filtered and recrystallized from 2-propanol to give the named compound as colorless needles.

Workup

  1. addition, the addition
  2. customthe flask is sealed
  3. filtrationThe solid that separates is filtered
  4. customrecrystallized from 2-propanol

Sources & evidence

ORD record
ord-a9cd76c6025645d1b23f923b504bbb9e
Source dataset
uspto-grants-1976_06
Patent number
US03965100

Reaction notes

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